The term infant's disease is called progeria. Progeria comes from the Latin "Geras" which means old age. Progeria is a genetic code fault disease that occurs mutation, the disease is more precisely a protein disorder (Lamin A) around the cell nucleus. Experts say this disorder occurs in chromosomal errors, resulting in premature aging. This aging process occurs 4 to 7 times that of normal aging.
There are two types of progeria that is Hutchinson-Griford syndrome is a progeria disorder that occurs in childhood and Werner syndrome is progeria that occurs in adulthood. Progeria is a non-infectious disease and is not a hereditary disease, it can happen to anyone regardless of gender or race. Progeria in infants occurs and new kembihatan between 2-year-old baby from birth.
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| Progeria Disease Causes - The Mutation of lamin A |
Progeria Disease Causes - The Mutation of Single Gene Called lamin A (LNMA)
The cause of progeria is due to the mutation of a single gene called lamin A (LNMA). The function of this gene produces a protein called prelamin A that works to keep the human cell nucleus stick together. When lamin A occurs mutations in the gene mutation will make the cell become unstable. Progeria is not affected by heredity.
Infants with progeria generally appear normal at birth. Progeria begins to show its symptoms the first few months after birth. Initially a baby with progeria will show symptoms of slowing down the growth process, namely the baby difficult to increase his weight.
Some people with progeria have skin that looks like scleroderma in the arms and legs. However, the development of motor and intelligence of infants with progeria still runs like in general.
Progeria of rare diseases and in Indonesia found only one person. While in the world, only one Progeria sufferer is present among 250,000 live births. Even so, there was also found a family with five children who are all Progeria sufferers. Currently, in the new world recorded 60 cases. The disease was first discovered in London, England, in 1752.
The sufferer often develops progressive atherosclerosis (vascular blockage disorder) as is commonly seen in elderly individuals. This can lead to a stroke or heart attack that leads to death. What should be noted is the buildup of cholesterol in the blood vessels, especially in the heart and intestines.
Treatment of progeria include the following:
- Farnesyltransferase Inhibitor (FTI). That is a type of cancer treatment that can be used with progeria disease to repair damage to body cells.
- Low dose aspirin
- Growth hormone. This hormone serves to inhibit the production of protein prelamin A abnormal. This hormone is also to help raise the weight.
- Cholesterol and Coagulation Drugs (KMY)
That's all about Progeria Disease Causes. This disease is caused by the mutation of a gene called lamin A. Even though you cannot deny progeria disease causes, you can do some treatments for sufferers.